Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls
Identifieur interne : 000945 ( Main/Exploration ); précédent : 000944; suivant : 000946Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls
Auteurs : Allison Buchanan [États-Unis] ; Ruben Cohen [États-Unis] ; Stephen Looney [États-Unis] ; Sajitha Kalathingal [États-Unis] ; Scott De Rossi [États-Unis]Source :
- Imaging Science in Dentistry [ 2233-7822 ] ; 2016.
Abstract
To evaluate the upper airway dimensions of obstructive sleep apnea (OSA) and control subjects using a cone-beam computed tomography (CBCT) unit commonly applied in clinical practice in order to assess airway dimensions in the same fashion as that routinely employed in a clinical setting.
This was a retrospective analysis utilizing existing CBCT scans to evaluate the dimensions of the upper airway in OSA and control subjects. The CBCT data of sixteen OSA and sixteen control subjects were compared. The average area, average volume, total volume, and total length of the upper airway were computed. Width and anterior-posterior (AP) measurements were obtained on the smallest axial slice.
OSA subjects had a significantly smaller average airway area, average airway volume, total airway volume, and mean airway width. OSA subjects had a significantly larger airway length measurement. The mean A-P distance was not significantly different between groups.
OSA subjects have a smaller upper airway compared to controls with the exception of airway length. The lack of a significant difference in the mean A-P distance may indicate that patient position during imaging (upright vs. supine) can affect this measurement. Comparison of this study with a future prospective study design will allow for validation of these results.
Url:
DOI: 10.5624/isd.2016.46.1.9
PubMed: 27051634
PubMed Central: 4816775
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000637
- to stream Pmc, to step Curation: 000637
- to stream Pmc, to step Checkpoint: 000799
- to stream Ncbi, to step Merge: 006607
- to stream Ncbi, to step Curation: 006607
- to stream Ncbi, to step Checkpoint: 006607
- to stream Main, to step Merge: 000945
- to stream Main, to step Curation: 000945
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls</title><author><name sortKey="Buchanan, Allison" sort="Buchanan, Allison" uniqKey="Buchanan A" first="Allison" last="Buchanan">Allison Buchanan</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cohen, Ruben" sort="Cohen, Ruben" uniqKey="Cohen R" first="Ruben" last="Cohen">Ruben Cohen</name><affiliation wicri:level="2"><nlm:aff id="A2">Park Avenue Oral and Facial Surgery, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Park Avenue Oral and Facial Surgery, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Looney, Stephen" sort="Looney, Stephen" uniqKey="Looney S" first="Stephen" last="Looney">Stephen Looney</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics and Epidemiology, Augusta University Medical College of Georgia, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics and Epidemiology, Augusta University Medical College of Georgia, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Oral Health and Diagnostic Sciences, Georgia Regents University, Dental College of Georgia, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Oral Health and Diagnostic Sciences, Georgia Regents University, Dental College of Georgia, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kalathingal, Sajitha" sort="Kalathingal, Sajitha" uniqKey="Kalathingal S" first="Sajitha" last="Kalathingal">Sajitha Kalathingal</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="De Rossi, Scott" sort="De Rossi, Scott" uniqKey="De Rossi S" first="Scott" last="De Rossi">Scott De Rossi</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27051634</idno><idno type="pmc">4816775</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816775</idno><idno type="RBID">PMC:4816775</idno><idno type="doi">10.5624/isd.2016.46.1.9</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000637</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000637</idno><idno type="wicri:Area/Pmc/Curation">000637</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000637</idno><idno type="wicri:Area/Pmc/Checkpoint">000799</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000799</idno><idno type="wicri:Area/Ncbi/Merge">006607</idno><idno type="wicri:Area/Ncbi/Curation">006607</idno><idno type="wicri:Area/Ncbi/Checkpoint">006607</idno><idno type="wicri:doubleKey">2233-7822:2016:Buchanan A:cone:beam:ct</idno><idno type="wicri:Area/Main/Merge">000945</idno><idno type="wicri:Area/Main/Curation">000945</idno><idno type="wicri:Area/Main/Exploration">000945</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls</title><author><name sortKey="Buchanan, Allison" sort="Buchanan, Allison" uniqKey="Buchanan A" first="Allison" last="Buchanan">Allison Buchanan</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cohen, Ruben" sort="Cohen, Ruben" uniqKey="Cohen R" first="Ruben" last="Cohen">Ruben Cohen</name><affiliation wicri:level="2"><nlm:aff id="A2">Park Avenue Oral and Facial Surgery, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Park Avenue Oral and Facial Surgery, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Looney, Stephen" sort="Looney, Stephen" uniqKey="Looney S" first="Stephen" last="Looney">Stephen Looney</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics and Epidemiology, Augusta University Medical College of Georgia, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics and Epidemiology, Augusta University Medical College of Georgia, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Oral Health and Diagnostic Sciences, Georgia Regents University, Dental College of Georgia, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Oral Health and Diagnostic Sciences, Georgia Regents University, Dental College of Georgia, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kalathingal, Sajitha" sort="Kalathingal, Sajitha" uniqKey="Kalathingal S" first="Sajitha" last="Kalathingal">Sajitha Kalathingal</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="De Rossi, Scott" sort="De Rossi, Scott" uniqKey="De Rossi S" first="Scott" last="De Rossi">Scott De Rossi</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">Imaging Science in Dentistry</title><idno type="ISSN">2233-7822</idno><idno type="eISSN">2233-7830</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To evaluate the upper airway dimensions of obstructive sleep apnea (OSA) and control subjects using a cone-beam computed tomography (CBCT) unit commonly applied in clinical practice in order to assess airway dimensions in the same fashion as that routinely employed in a clinical setting.</p></sec><sec><title>Materials and Methods</title><p>This was a retrospective analysis utilizing existing CBCT scans to evaluate the dimensions of the upper airway in OSA and control subjects. The CBCT data of sixteen OSA and sixteen control subjects were compared. The average area, average volume, total volume, and total length of the upper airway were computed. Width and anterior-posterior (AP) measurements were obtained on the smallest axial slice.</p></sec><sec><title>Results</title><p>OSA subjects had a significantly smaller average airway area, average airway volume, total airway volume, and mean airway width. OSA subjects had a significantly larger airway length measurement. The mean A-P distance was not significantly different between groups.</p></sec><sec><title>Conclusion</title><p>OSA subjects have a smaller upper airway compared to controls with the exception of airway length. The lack of a significant difference in the mean A-P distance may indicate that patient position during imaging (upright vs. supine) can affect this measurement. Comparison of this study with a future prospective study design will allow for validation of these results.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Holty, Je" uniqKey="Holty J">JE Holty</name></author><author><name sortKey="Guilleminault, C" uniqKey="Guilleminault C">C Guilleminault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Susarla, Sm" uniqKey="Susarla S">SM Susarla</name></author><author><name sortKey="Thomas, Rj" uniqKey="Thomas R">RJ Thomas</name></author><author><name sortKey="Abramson, Zr" uniqKey="Abramson Z">ZR Abramson</name></author><author><name sortKey="Kaban, Lb" uniqKey="Kaban L">LB Kaban</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogawa, T" uniqKey="Ogawa T">T Ogawa</name></author><author><name sortKey="Enciso, R" uniqKey="Enciso R">R Enciso</name></author><author><name sortKey="Shintaku, Wh" uniqKey="Shintaku W">WH Shintaku</name></author><author><name sortKey="Clark, Gt" uniqKey="Clark G">GT Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epstein, Lj" uniqKey="Epstein L">LJ Epstein</name></author><author><name sortKey="Kristo, D" uniqKey="Kristo D">D Kristo</name></author><author><name sortKey="Strollo, Pj" uniqKey="Strollo P">PJ Strollo</name></author><author><name sortKey="Friedman, N" uniqKey="Friedman N">N Friedman</name></author><author><name sortKey="Malhotra, A" uniqKey="Malhotra A">A Malhotra</name></author><author><name sortKey="Patil, Sp" uniqKey="Patil S">SP Patil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jg" uniqKey="Park J">JG Park</name></author><author><name sortKey="Ramar, K" uniqKey="Ramar K">K Ramar</name></author><author><name sortKey="Olson, Ej" uniqKey="Olson E">EJ Olson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korayem, Mm" uniqKey="Korayem M">MM Korayem</name></author><author><name sortKey="Witmans, M" uniqKey="Witmans M">M Witmans</name></author><author><name sortKey="Maclean, J" uniqKey="Maclean J">J MacLean</name></author><author><name sortKey="Heo, G" uniqKey="Heo G">G Heo</name></author><author><name sortKey="El Hakim, H" uniqKey="El Hakim H">H El-Hakim</name></author><author><name sortKey="Flores Mir, C" uniqKey="Flores Mir C">C Flores-Mir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sonnesen, L" uniqKey="Sonnesen L">L Sonnesen</name></author><author><name sortKey="Jensen, Ke" uniqKey="Jensen K">KE Jensen</name></author><author><name sortKey="Petersson, Ar" uniqKey="Petersson A">AR Petersson</name></author><author><name sortKey="Petri, N" uniqKey="Petri N">N Petri</name></author><author><name sortKey="Berg, S" uniqKey="Berg S">S Berg</name></author><author><name sortKey="Svanholt, P" uniqKey="Svanholt P">P Svanholt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwab, Rj" uniqKey="Schwab R">RJ Schwab</name></author><author><name sortKey="Pasirstein, M" uniqKey="Pasirstein M">M Pasirstein</name></author><author><name sortKey="Pierson, R" uniqKey="Pierson R">R Pierson</name></author><author><name sortKey="Mackley, A" uniqKey="Mackley A">A Mackley</name></author><author><name sortKey="Hachadoorian, R" uniqKey="Hachadoorian R">R Hachadoorian</name></author><author><name sortKey="Arens, R" uniqKey="Arens R">R Arens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enciso, R" uniqKey="Enciso R">R Enciso</name></author><author><name sortKey="Shigeta, Y" uniqKey="Shigeta Y">Y Shigeta</name></author><author><name sortKey="Nguyen, M" uniqKey="Nguyen M">M Nguyen</name></author><author><name sortKey="Clark, Gt" uniqKey="Clark G">GT Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Camacho, M" uniqKey="Camacho M">M Camacho</name></author><author><name sortKey="Capasso, R" uniqKey="Capasso R">R Capasso</name></author><author><name sortKey="Schendel, S" uniqKey="Schendel S">S Schendel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conley, Rs" uniqKey="Conley R">RS Conley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mozzo, P" uniqKey="Mozzo P">P Mozzo</name></author><author><name sortKey="Procacci, C" uniqKey="Procacci C">C Procacci</name></author><author><name sortKey="Tacconi, A" uniqKey="Tacconi A">A Tacconi</name></author><author><name sortKey="Martini, Pt" uniqKey="Martini P">PT Martini</name></author><author><name sortKey="Andreis, Ia" uniqKey="Andreis I">IA Andreis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ludlow, Jb" uniqKey="Ludlow J">JB Ludlow</name></author><author><name sortKey="Ivanovic, M" uniqKey="Ivanovic M">M Ivanovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abramson, Z" uniqKey="Abramson Z">Z Abramson</name></author><author><name sortKey="Susarla, Sm" uniqKey="Susarla S">SM Susarla</name></author><author><name sortKey="Lawler, M" uniqKey="Lawler M">M Lawler</name></author><author><name sortKey="Bouchard, C" uniqKey="Bouchard C">C Bouchard</name></author><author><name sortKey="Troulis, M" uniqKey="Troulis M">M Troulis</name></author><author><name sortKey="Kaban, Lb" uniqKey="Kaban L">LB Kaban</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enciso, R" uniqKey="Enciso R">R Enciso</name></author><author><name sortKey="Nguyen, M" uniqKey="Nguyen M">M Nguyen</name></author><author><name sortKey="Shigeta, Y" uniqKey="Shigeta Y">Y Shigeta</name></author><author><name sortKey="Ogawa, T" uniqKey="Ogawa T">T Ogawa</name></author><author><name sortKey="Clark, Gt" uniqKey="Clark G">GT Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayer, P" uniqKey="Mayer P">P Mayer</name></author><author><name sortKey="Pepin, Jl" uniqKey="Pepin J">JL Pepin</name></author><author><name sortKey="Bettega, G" uniqKey="Bettega G">G Bettega</name></author><author><name sortKey="Veale, D" uniqKey="Veale D">D Veale</name></author><author><name sortKey="Ferretti, G" uniqKey="Ferretti G">G Ferretti</name></author><author><name sortKey="Deschaux, C" uniqKey="Deschaux C">C Deschaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alsufyani, Na" uniqKey="Alsufyani N">NA Alsufyani</name></author><author><name sortKey="Al Saleh, Ma" uniqKey="Al Saleh M">MA Al-Saleh</name></author><author><name sortKey="Major, Pw" uniqKey="Major P">PW Major</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hora, F" uniqKey="Hora F">F Hora</name></author><author><name sortKey="Napolis, Lm" uniqKey="Napolis L">LM Napolis</name></author><author><name sortKey="Daltro, C" uniqKey="Daltro C">C Daltro</name></author><author><name sortKey="Kodaira, Sk" uniqKey="Kodaira S">SK Kodaira</name></author><author><name sortKey="Tufik, S" uniqKey="Tufik S">S Tufik</name></author><author><name sortKey="Togeiro, Sm" uniqKey="Togeiro S">SM Togeiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsuiki, S" uniqKey="Tsuiki S">S Tsuiki</name></author><author><name sortKey="Almeida, Fr" uniqKey="Almeida F">FR Almeida</name></author><author><name sortKey="Bhalla, Ps" uniqKey="Bhalla P">PS Bhalla</name></author><author><name sortKey="A Lowe, Aa" uniqKey="A Lowe A">AA A Lowe</name></author><author><name sortKey="Fleetham, Ja" uniqKey="Fleetham J">JA Fleetham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fairburn, Sc" uniqKey="Fairburn S">SC Fairburn</name></author><author><name sortKey="Waite, Pd" uniqKey="Waite P">PD Waite</name></author><author><name sortKey="Vilos, G" uniqKey="Vilos G">G Vilos</name></author><author><name sortKey="Harding, Sm" uniqKey="Harding S">SM Harding</name></author><author><name sortKey="Bernreuter, W" uniqKey="Bernreuter W">W Bernreuter</name></author><author><name sortKey="Cure, J" uniqKey="Cure J">J Cure</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Buchanan, Allison" sort="Buchanan, Allison" uniqKey="Buchanan A" first="Allison" last="Buchanan">Allison Buchanan</name></region><name sortKey="Cohen, Ruben" sort="Cohen, Ruben" uniqKey="Cohen R" first="Ruben" last="Cohen">Ruben Cohen</name><name sortKey="De Rossi, Scott" sort="De Rossi, Scott" uniqKey="De Rossi S" first="Scott" last="De Rossi">Scott De Rossi</name><name sortKey="Kalathingal, Sajitha" sort="Kalathingal, Sajitha" uniqKey="Kalathingal S" first="Sajitha" last="Kalathingal">Sajitha Kalathingal</name><name sortKey="Looney, Stephen" sort="Looney, Stephen" uniqKey="Looney S" first="Stephen" last="Looney">Stephen Looney</name><name sortKey="Looney, Stephen" sort="Looney, Stephen" uniqKey="Looney S" first="Stephen" last="Looney">Stephen Looney</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000945 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000945 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4816775
|texte= Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27051634" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |